Current Projects
(The links below will be redirected to our US partner fpwr.org)
Current Projects Funded by FPWR Canada
-
REVEALING THE MOLECULAR ARCHITECTURE OF PWS THROUGH LARGE LANGUAGE MODELS FOR TARGETED DRUG REPURPOSING
Year: 2024
Investigator: Dr. Rohit Singh
Location: Ohio State University
Amount in CAD Funds: $65,000.00 -
Using Functional Near-Infrared Spectroscopy to Identify Biomarkers of Skin Picking Behavior in PWS
Year: 2023
Investigator: Dr. Scott Hall
Location: Stanford University
Amount in CAD Funds: $90,000.00 -
The Role of Microglia in Prader-Willi Syndrome and a Hypothalamic Gene Therapy
Year: 2023
Investigator: Dr. Lei Cao
Location: Ohio State University
Amount in CAD Funds: $90,000.00 -
Unraveling the Mechanism of PWS by Molecular Dissection of Driver Genes in Hypothalamic Neuron Model, Year 2
Year: 2022
Investigator: Dr. Derek Tai
Location: University of Michigan
Amount in CAD Funds: $146,222.00 -
Determining Beloranib’s Mechanism of Action to Inform Novel Drug Targets for PWS
Year: 2022
Investigator: Dr. Sarah Mitchell
Location: ETH Zurich
Amount in CAD Funds: $146,222.00 -
Unraveling the Mechanism of PWS by Molecular Dissection of Driver Genes in Hypothalamic Neuron Model, Year 2
Year: 2021
Investigator: Dr. Derek Tai
Location: Massachusetts General Hospital
Amount in CAD Funds: $149,018.00 -
Role of MAGEL2 in Excitatory Synapse Function – PWS gene effects on oxytocin and brain cell communication
Year: 2020
Investigator: Dr. Deniz Atasoy
Location: University of Iowa
Amount in CAD Funds: $84,838.00 -
Neuronal Mechanisms of Developmental Cognitive Impairment in the SNORD116Del Mouse Model for Prader-Willi Syndrome – How neurons develop differently in PWS
Year: 2020
Investigator: Dr. Timothy Wells
Location: Cardiff University
Amount in CAD Funds: $4,713.00 -
Allele-Specific DNA Replication Timing of the Prader-Willi Locus and its Influence on Neuronal Development – Brain cell replication in PWS has defective DNA, which might cause some of the PWS developmental effects
Year: 2020
Investigator: Dr. Amnon Koren
Location: Cardiff University
Amount in CAD Funds: $70,698.00 -
Investigating a new potential target for treatment in Prader-Willi Syndrome
Year: 2019
Investigator: Dr. Lauren Rice
Location: University of Sydney
Amount in CAD Funds: $200,428.00 -
Understanding the role of microglia in the Prader-Willi Hypothalamus
Year: 2018
Investigator: Dr. Deborah Kurrasch
Location: University of Calgary
Amount in CAD Funds: $142,461.00 -
Chronic Stress, cognition, and food cue reactivity in PWS: A Magnetoencephalography study Year: 2018
Year: 2018
Investigator: Dr. Jill Hamilton
Location: Hospital for Sick Children Toronto
Amount in CAD Funds: $147,689.00 -
Systematic Investigation of Early Social Cognitive Processes and the Feasibility of Intervention Year: 2017
Year: 2017
Investigator: Dr. Anastasia Dimitropoulos
Location: Case Western University, Ohio
Amount in CAD Funds: $100,252.00 -
Dissecting a novel brainstem feeding circuit in Prader-Willi Syndrome
Year: 2017
Investigator: Alexander Nectow
Location: Princeton University
Amount in CAD Funds: $135,389.00 -
A Mindfulness-based intervention for temper outbursts in Prader-Willi Syndrome.
Year: 2017
Investigator: Stewart Einfeld
Location: University of Sydney, Australia
Amount in CAD Funds: $60,766.00 -
Improving social functioning in Prader-Willi syndrome
Year: 2017
Investigator: Elisabeth Dykens
Location: Vanderbilt University
Amount in CAD Funds: $147,538.00 -
Therapeutic Potential of Blocking Zinc Finger Protein 274 Binding to the PWS Locus
Year: 2017
Investigator: Marc Lalande, PhD
Location: University of Connecticut Health Center
Amount in CAD Funds: $72,842.00 -
Mitochondrial Complex I dysfunction in Prader Willi Syndrome: A new therapeutic target
Year: 2016
Investigator: Dr. Ingrid Tein
Location: Hospital for Sick Kids, Toronto
Amount in CAD Funds: $71,555.00 -
Impact of carbohydrate restricted diet upon growth and hyperphagia/food anxiety in children with Prader-Willi Syndrome
Year: 2016
Investigator: Ann Scheimann, MD
Location: Johns Hopkins University
Amount in CAD Funds: $150,514.00 -
Loss of MAGEL2 and hypotonia in Prader-Willi Syndrome
Year: 2016
Investigator: Rachel Wevrick, PhD
Location: University of Alberta
Amount in CAD Funds: $111,821.00 -
Role of melanin concentrating hormone in an animal model of Prader-Willi Syndrome
Year: 2015
Investigator: Michiru Hirasawa, DVM, PhD
Location: Memorial University of Newfoundland, St. John’s
Amount in CAD Funds: $84,000.00 -
Characterisation of anti-ghrelin autoantibodies in Prader-Willi Syndrome
Year: 2015
Investigator: Lisa Chopin, DVM, PhD
Location: Queensland University of Technology, Australia
Amount in CAD Funds: $158,431.00 -
Reactivation of the PWS locus via disruption of the ZNF274 silencing complex
Year: 2014
Investigator: Marc Lalande, PhD
Location: University of Connecticut Health Center
Amount in CAD Funds: $129,027.00 -
Small Molecules and Therapeutic Potential for PWS
Year: 2014
Investigator: Yong-Hui Jiang,PhD
Location: Duke University, Durham NC
Amount in CAD Funds: $21,710.00